Associations of cardiac function and arterial stiffness with cerebrovascular disease
Publication Type
Journal Article
Publication Date
7-2024
Abstract
Background: White matter hyperintensities (WMHs) represent diffuse small vessel disease implicating the cardiac, systemic, and cerebral vasculatures. As the brain may be the end-organ of cumulative vascular disease, and higher education is protective of both cardiovascular and brain health, we aim to clarify their intertwining relationships. Methods: We evaluated participants (mean age = 64) from the UK Biobank with neuroimaging measures of WMHs, left ventricular ejection fraction (LVEF) quantified using cardiovascular MRI, and arterial stiffness index (ASI) quantified using finger photoplethysmography. We used multiple regression to evaluate the basic, independent, and interactive relationships of LVEF status ( n = 27,512) and ASI ( n = 33,584) with WMHs. Moderated mediation analysis was used to determine whether the relationship between LVEF status and WMH was mediated by ASI and moderated by education. Results: Abnormal LVEF (8 = -0.082, p
Keywords
White matter hyperintensities, Left ventricular ejection fraction, Arterial stiffness index, Education, Cognitive reserve
Discipline
Health Psychology
Research Areas
Psychology
Publication
International Journal of Cardiology
Volume
407
ISSN
0167-5273
Identifier
https://doi.org/10.1016/j.ijcard.2024.132037
Publisher
Elsevier
Citation
TAN, Chin Hong., & TAN, Jacinth Jia Xin.(2024). Associations of cardiac function and arterial stiffness with cerebrovascular disease. International Journal of Cardiology, 407.
Available at: https://ink.library.smu.edu.sg/soss_research/4110
Additional URL
https://doi.org/10.1016/j.ijcard.2024.132037