Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition
Publication Type
Journal Article
Publication Date
4-2023
Abstract
There is increasing recognition that socioeconomic inequalities contribute to disparities in brain and cognitive health in older adults. However, whether neighborhood socioeconomic status (SES) buffers individuals with low individual SES against neurodegeneration, cerebrovascular disease, and poorer cognitive function is not well understood. Here, we evaluated whether neighborhood deprivation (Townsend deprivation index) interacted with individual SES (composite household income and education levels) on hippocampus volume, regional cortical thickness, white matter hyperintensities, and cognition in 19,638 individuals (mean age = 54.8) from the UK Biobank. We found that individuals with low individual SES had the smallest hippocampal volumes, greatest white matter hyperintensity burden, and poorest cognition if they were living in high deprivation neighborhoods but that these deleterious effects on brain and cognitive function were attenuated if they were living in low deprivation neighborhoods (p for interactions
Keywords
socioeconomic inequalities, brain and cognitive health, older adults, neighborhood socioeconomic status (SES), neurodegeneration, cerebrovascular disease, cognitive function, neighborhood deprivation, Townsend deprivation index, individual SES, household income, education levels, hippocampus volume, cortical thickness, white matter hyperintensities, cognition, UK Biobank, vulnerability, neuroprotective effect
Discipline
Cognition and Perception | Gerontology
Research Areas
Psychology
Publication
GeroScience
Volume
45
Issue
3
First Page
2027
Last Page
2036
ISSN
2509-2715
Identifier
10.1007/s11357-023-00780-y
Publisher
Springer
Citation
TAN, Chin Hong, & TAN, Jacinth Jia Xin.(2023). Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition. GeroScience, 45(3), 2027-2036.
Available at: https://ink.library.smu.edu.sg/soss_research/3890
Additional URL
https://doi.org/10.1007/s11357-023-00780-y