Effect of Microscopic Resection Line Disease on Gastric-Cancer Survival

Publication Type

Journal Article

Publication Date

1999

Abstract

To study the effect of residual microscopic resection line disease in gastric cancer, we compared 47 patients with positive margins to 572 patients who underwent R0 resections using a multivariate analysis of factors affecting outcome. Although the presence of positive margins was a significant and independent predictor of outcome for the entire group (N = 619), this factor lost significance in patients who had undergone D2 or D3 lymph node dissections (N = 466). Subset analysis within the D2/D3 group determined that this finding was limited mainly to those patients with.5 positive nodes (N = 189). The survival of patients who had 5 positive nodes. We conclude that the significance of a positive microscopic margin in gastric cancer is dependent on the extent of disease. This factor is not predictive of outcome in patients who have undergone complete gross resection and have pathologically proved advanced nodal disease. Thus the goal in these cases should be an R0 resection when feasible but with the realization that the presence of >/=5 positive nodes (N2 disease according to the 1997 American Joint Committee on Cancer criteria) will mainly determine outcome and not microscopic residual cancer at the margin.

Discipline

Economics

Research Areas

Econometrics

Publication

Journal of Gastrointestinal Surgery

Volume

3

Issue

1

First Page

24

Last Page

33

ISSN

1091-255X

Identifier

10.1016/s1091-255x(99)80004-3

Publisher

Elsevier

Additional URL

https://doi.org/10.1016/s1091-255x(99)80004-3

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