Publication Type

Journal Article

Version

publishedVersion

Publication Date

5-2002

Abstract

Hepatocellular carcinoma (HCC or hepatoma) is the most common primary cancer of the liver. Persistent viral infection by the hepatic B or C virus is probably the most important cause of HCC worldwide. It is responsible for approximately one million deaths each year, predominantly in the underdeveloped and developing countries, but its incidence is also on the rise in the developed countries. For most patients suffering from HCC, long-term survival is rare, as they are presented late and are often unsuitable for curative treatment. Thus there is great interest to identify novel HCC diagnostic markers for early detection of the disease, and tumour specific associated proteins as potential therapeutic targets in the treatment of HCC. Proteome analyses of HCC cell lines and liver tumour tissues should facilitate the screening and discovery of these HCC proteins. The creation of a comprehensive HCC proteome database would be an important first step towards achieving this goal. This review presents an update of the two-dimensional electrophoresis proteome database of the cell line, HCC-M, which is also now freely accessible through the World Wide Web at http://proteome.btc.nus.edu.sg/hccm/.

Keywords

Reviews, Proteomics, Hepatocellular carcinoma

Discipline

Computer Engineering | Databases and Information Systems

Research Areas

Data Science and Engineering

Publication

Journal of Chromatography B

Volume

771

Issue

1-2

First Page

303

Last Page

328

ISSN

1570-0232

Identifier

10.1016/s1570-0232(02)00041-7

Publisher

Elsevier

Additional URL

https://doi.org/10.1016/s1570-0232(02)00041-7

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