Hybrid outcome prediction model for severe traumatic brain injury

Publication Type

Journal Article

Publication Date

1-2007

Abstract

Numerous studies addressing different methods of head injury prognostication have been published. Unfortunately, these studies often incorporate different head injury prognostication models and study populations, thus making direct comparison difficult, if not impossible. Furthermore, newer artiricial intelligence tools such as machine learning methods have evolved in the field of data analysis, alongside more traditional methods of analysis. This study targets the development of a set of integrated prognostication model combining different classes of outcome and prognostic factors. Methodologies such as discriminant analysis, logistic regression, decision tree, Bayesian network, and neural network were employed in the study. Several prognostication models were developed using prospectively collected data from 513 severe closed head-injured patients admitted to the Neurocritical Unit at National Neuroscience Institute of Singapore, from April 1999 to February 2003. The correlation between prognostic factors at admission and outcome at 6 months following injury was studied. Overritting error, which may falsely distinguish different outcomes, was compared graphically. Tenfold cross-validation technique, which reduces overfitting error, was used to validate outcome prediction accuracy. The overall prediction accuracy achieved ranged from 49.79% to 81.49%. Consistently high outcome prediction accuracy was seen with logistic regression and decision tree. Combining both logistic regression and decision tree models, a hybrid prediction model was then developed. This hybrid model would more accurately predict the 6-month post-severe head injury outcome using baseline admission parameters.

Keywords

Adult brain injury, Assessment tools, Bayesian network, Discriminant analysis, Human studies, Logistic regression, Neural network, Outcome measures, Traumatic brain injuries

Discipline

Computer Sciences | Health Information Technology

Publication

Journal of Neurotrauma

Volume

24

Issue

1

First Page

136

Last Page

146

ISSN

0897-7151

Identifier

10.1089/neu.2006.0113

Publisher

Mary Ann Liebert

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