Publication Type

Journal Article

Version

publishedVersion

Publication Date

11-2021

Abstract

A principal task in dissecting the genetics of complex traits is to identify causal genes for disease phenotypes. Millions of genes have been sequenced in data-driven genomics era, but their causal relationships with disease phenotypes remain limited, due to the difficulty of elucidating underlying causal genes by laboratory-based strategies. Here, we proposed an innovative deep learning computational modeling alternative (DPPCG framework) for identifying causal (coding) genes for a specific disease phenotype. In terms of male infertility, we introduced proteins as intermediate cell variables, leveraging integrated deep knowledge representations (Word2vec, ProtVec, Node2vec, and Space2vec) quantitatively represented as ‘protein deep profiles’. We adopted deep convolutional neural network (CNN) classifier to model protein deep profiles relationships with male infertility, creatively training deep CNN models of single-label binary classification and multi-label eight classification. We demonstrate the capabilities of DPPCG framework by integrating and fully harnessing the utility of heterogeneous biomedical big data, including literature, protein sequences, protein–protein interactions, gene expressions, and gene–phenotype relationships, and effective indirect prediction of 794 causal genes of male infertility and associated pathological processes. We present this research in an interactive ‘Smart Protein’ intelligent (demo) system (http://www.smartprotein.cloud/public/home). Researchers can benefit from our intelligent system by (i) accessing a shallow gene/protein-radar service involving research status and a knowledge graph-based vertical search; (ii) querying and downloading protein deep profile matrices; (iii) accessing intelligent recommendations for causal genes of male infertility and associated pathological processes, and references for model architectures, parameter settings, and training outputs; and (iv) carrying out personalized analysis such as online K-Means clustering.

Keywords

Data integration, Disease phenotype, Male infertility, Causal gene, Knowledge representation, Convolutional neural network, Manifold learning, Deep learning

Discipline

Databases and Information Systems

Research Areas

Data Science and Engineering

Areas of Excellence

Digital transformation

Publication

Information Fusion: An International Journal on Multi-Sensor, Multi-Source Information Fusion

Volume

75

First Page

70

Last Page

89

ISSN

1566-2535

Identifier

10.1016/j.inffus.2021.04.012

Publisher

Elsevier

Additional URL

https://doi.org/10.1016/j.inffus.2021.04.012

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