Publication Type
Journal Article
Version
acceptedVersion
Publication Date
9-2017
Abstract
Identifying asymptomatic older individuals at elevated risk for developing Alzheimer's disease (AD) is of clinical importance. Among 1,081 asymptomatic older adults, a recently validated polygenic hazard score (PHS) significantly predicted time to AD dementia and steeper longitudinal cognitive decline, even after controlling for APOE e4 carrier status. Older individuals in the highest PHS percentiles showed the highest AD incidence rates. PHS predicted longitudinal clinical decline among older individuals with moderate to high CERAD (amyloid) and Braak (tau) scores at autopsy, even among APOE e4 non-carriers. Beyond APOE, PHS may help identify asymptomatic individuals at highest risk for developing Alzheimer's neurodegeneration.
Keywords
Polygenic risk, Preclinical AD
Discipline
Diseases | Psychology
Research Areas
Psychology
Publication
Annals of Neurology
Volume
82
Issue
3
First Page
484
Last Page
488
ISSN
0364-5134
Identifier
10.1002/ana.25029
Publisher
Wiley: 12 months
Citation
TAN, Chin Hong, HYMAN, Bradley T., TAN, Jacinth J. X., HESS, Christopher P., DILLON, William P., SCHELLENBERG, Gerard D., BESSER, Lilah M., KUKULL, Walter A., KAUPPI, Karolina, MCEVOY, Linda K., ANDREASSEN, Ole A., DALE, Anders M., FAN, Chun Chieh, & DESIKAN, Rahul S..(2017). Polygenic hazard scores in preclinical Alzheimer's disease. Annals of Neurology, 82(3), 484-488.
Available at: https://ink.library.smu.edu.sg/soss_research/2744
Copyright Owner and License
Authors
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Additional URL
https://doi.org/10.1002/ana.25029