Induction Dose-Response of Propofol in Unpremedicated Children

Publication Type

Journal Article

Publication Date

1992

Abstract

The induction dose requirements of propofol were compared in three age groups in 300 unpre-medicated healthy Chinese children: group A, younger than 2 yr (n = 48); group B, 2–5 yr (n = 117); group C, 6–12 yr (n = 135). Patients in each group were allocated randomly to receive one of eight doses of propofol (1.2, 1.4, 1.6, 1.8, 2.0, 2.2, 2.4 and 2.6 mg kg–1J). ED50 and ED95 for loss of eyelash reflex (LER) and acceptance of face mask (AFM) were determined using probit analysis. ED50 and ED95 for both LER and AFM were greatest in group A, less in B and smallest in C; ED95 (AFM) for groups A, B and C were 2.88 (2.55–3.36). 2.53 (2.31–2.86), and2.20 (2.02–2.46) mg kg–1, respectively. This probably represented their effective induction dose. The incidence of apnoea was dose related, but not pain on injection.

Discipline

Econometrics | Medicine and Health Sciences

Research Areas

Econometrics

Publication

British Journal of Anaesthesia

Volume

58

Issue

1

First Page

64

Last Page

67

ISSN

0007-0912

Identifier

10.1093/bja/68.1.64

Publisher

Oxford University Press

Additional URL

https://doi.org/10.1093/bja/68.1.64

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