Publication Type
Journal Article
Version
submittedVersion
Publication Date
12-2021
Abstract
Acute kidney injury (AKI) is a frequent complication of cardiac surgery, which can lead to higher mortality and long-term renal function impairment. The effect of perioperative renin-angiotensin system inhibitors (RASi) therapy on AKI incidence in patients undergoing cardiac surgery remains controversial. We reviewed related studies in PubMed, Scopus, and Cochrane Library from inception to February 2020. Two randomized controlled trials and 21 cohort studies were included in the meta-analysis, involving 76,321 participants. The pooled odds ratio and 95% confidence interval were calculated using the DerSimonian and Laird random-effects model. The results showed no significant association between perioperative RASi therapy and postoperative AKI in patients undergoing cardiac surgery. We highlighted the limitations of existing studies and called for well-designed large-scale randomized controlled trials to verify the conclusion.
Keywords
Acute kidney injury, Cardiac surgery, Renin-angiotensin system inhibitors, Angiotensin-converting enzyme inhibitors, Angiotensin II receptor blockers
Discipline
Biostatistics | Medicine and Health Sciences
Research Areas
Operations Management
Publication
Seminars in Thoracic and Cardiovascular Surgery
Volume
33
Issue
4
First Page
1014
Last Page
1022
ISSN
1043-0679
Publisher
Elsevier
Embargo Period
3-24-2021
Citation
ZHOU, Han; XIE, Jingui; ZHENG, Zhichao; OOI, Oon Cheong; and LUO, Haidong.
Effect of renin-angiotensin system inhibitors on acute kidney injury among patients undergoing cardiac surgery: A review and meta-analysis. (2021). Seminars in Thoracic and Cardiovascular Surgery. 33, (4), 1014-1022.
Available at: https://ink.library.smu.edu.sg/lkcsb_research/6668
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Additional URL
https://doi.org/10.1053/j.semtcvs.2020.11.024