Title

Histopathologic Type: An Independent Prognostic Factor in Primary Soft Tissue Sarcoma of the Extremity?

Publication Type

Journal Article

Publication Date

2003

Abstract

We attempted to define the effect of tumor histotype on local recurrence, distant metastasis, and disease-specific survival in patients with surgically treated primary extremity sarcoma. Methods: A total of 951 patients with primary, localized soft tissue extremity sarcoma were followed up prospectively. Patient- and tumor-related variables, including histopathologic type, were used to identify independent prognostic factors for the study end points of local recurrence, distant recurrence, and disease-specific survival. Results: There were 137 local recurrences, and significant adverse prognostic factors for local recurrence were patient age >50 years, microscopically positive margins, and malignant peripheral nerve tumor. Adverse prognostic factors for distant recurrence (200 patients) were tumor size >5 cm, tumors beneath the investing fascia, high tumor grade, and leiomyosarcoma. Of the 199 patients who died of disease-related causes, patient age >50 years, tumors beneath the investing fascia, high tumor grade, microscopically positive margin, tumor size >5 cm, leiomyosarcoma, and malignant peripheral nerve tumor were adverse prognostic factors. Conclusions: These data suggest that differences in biological behavior may exist between sarcoma histotypes and deserve further study.

Keywords

Soft tissue sarcoma—Histopathology—Mortality—Prognostic factors

Discipline

Econometrics | Medicine and Health Sciences

Research Areas

Econometrics

Publication

Annals of Surgical Oncology

Volume

10

Issue

4

First Page

432

Last Page

440

ISSN

1068-9265

Identifier

10.1245/ASO.2003.05.014

Publisher

Lippincott Wiliams and Wilkins

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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