Amputation for Recurrent Soft Tissue Sarcoma of the Extremity: Indications and Outcome
Limb salvage after primary site failure of extremity soft tissue sarcoma is a challenging problem. Amputation may be the most effective treatment option in selected patients with local recurrence. We compared the outcome of patients treated with amputation versus limb-sparing surgery (LSS) for locally recurrent extremity sarcoma. Methods: From 1982 to 2000, 1178 patients with localized primary extremity sarcoma underwent LSS. Of these, 204 (17%) developed local recurrence. Eighteen (9%) required major amputation and the remainder underwent LSS, of which 34 were selected for matched-pair analysis according to established prognostic variables. Rates of recurrence or death were estimated by the Kaplan-Meier method. Following adjustment for prognostic variables, a Mantel-Haenszel test was used to compare the outcome between the two treatment groups. Results: Patients in each group were well matched. All patients had high-grade tumors deep to the fascia. Median time to local recurrence was similar for both groups. Median follow-up was 95 months. Amputation was associated with a significant improvement in local control of disease (94% vs. 74%; P = .04). We observed no difference in disease-free ( P = .48), disease-specific ( P = .74), or overall survival ( P = .93) between the two groups. Median postrecurrence survival was 20 months and 5-year OS was 36% for the entire study group. Conclusions: Limb-sparing treatment achieves local control in the majority of recurrent extremity sarcomas for which amputation is infrequently indicated. Amputation improves local disease control but not survival under these circumstances.
Econometrics | Medicine and Health Sciences
Annals of Surgical Oncology
Lippincott Wiliams and Wilkins
Stojadinovic, A.; Jaques, D. P.; Leung, Denis H. Y.; Healey, J.; and Brennan, M. F..
Amputation for Recurrent Soft Tissue Sarcoma of the Extremity: Indications and Outcome. (2001). Annals of Surgical Oncology. 8, (6), 509-518. Research Collection School Of Economics.
Available at: http://ink.library.smu.edu.sg/soe_research/466