Title

Antifibrinolytic Therapy and Perioperative Blood Loss in Cancer Patients Undergoing Major Orthopedic Surgery

Publication Type

Journal Article

Publication Date

2003

Abstract

Background: Aprotinin has been reported to reduce blood loss and transfusion requirements in patients having major orthopedic operations. Data on whether ? amino-caproic acid (EACA) is effective in this population are sparse. Methods: Sixty-nine adults with malignancy scheduled for either pelvic, extremity or spine surgery during general anesthesia entered this randomized, double-blind, placebo-controlled trial, and received either intravenous aprotinin (n = 23), bolus of 2 x 106 kallikrein inactivator units (KIU), followed by an infusion of 5 x 105 KIU/h, or EACA (n = 22), bolus of 150 mg/kg, followed by a 15 mg/kg/h infusion or saline placebo (n = 24) during surgery. Our goal was to determine whether prophylactic EACA or aprotinin therapy would reduce perioperative blood loss (intraoperative + first 48h) > 30% when compared to placebo. Results: The mean age of the study population was 52 ± 17 yr. The groups did not differ in age, duration of surgery, perioperative blood loss or number of packed erythrocyte units transfused. When compared to the placebo group, the two treated groups had a significantly lower D-Dimer level immediately after surgery, P < 0.01. Conclusions: Under the conditions of this study, we were unable to find a clinical benefit to using aprotinin or EACA to reduce perioperative blood loss or transfusion requirements during major orthopedic surgery in cancer patients.

Discipline

Econometrics | Medicine and Health Sciences

Research Areas

Econometrics

Publication

Anesthesiology

Volume

98

Issue

2

First Page

337

Last Page

342

ISSN

0003-3022

Publisher

Lippincott Wiliams and Wilkins

Additional URL

http://www.ncbi.nlm.nih.gov/pubmed/12552190

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