Title

Involvement of Bone or Neurovascular Structures by Soft Tissue Sarcoma at Mr Imaging as Prognostic Factors

Publication Type

Journal Article

Publication Date

1997

Abstract

To determine if magnetic resonance (MR) imaging findings of soft-tissue sarcoma involving bone or neurovascular structures allow prediction of local recurrence, distant metastasis, or disease-specific survival. MATERIALS AND METHODS: Preoperative MR images of 46 patients with soft-tissue sarcoma were reviewed for tumor involving bone or major vessels or nerves. MR imaging findings were correlated with local recurrence, distant metastasis, and disease-specific survival after surgery and chemotherapy and/or radiation therapy. Primary tumors were predominantly in the lower extremity (n = 35 [76%]), deep (n = 44 [96%]), and high-grade (n = 35 [76%]). RESULTS: On MR images, bone invasion occurred in 12 patients (26%), major-vessel encasement in five patients (11%), and major-nerve encasement in seven patients (15%). In patients with (n = 12) and those without (n = 34) bone invasion, frequencies of disease-related death (in nine [75%] and 12 [35%] patients, respectively) were significantly different (P = .02); frequencies of local recurrence or distant metastasis were not significantly different. In patients with and those without major- vessel or major-nerve encasement, there were no significant differences between frequencies of local recurrence, distant metastasis, or disease- specific survival. CONCLUSION: In soft-tissue sarcoma, bone invasion on MR images was predictive of decreased disease-specific survival. MR imaging findings of bone or neurovascular involvement otherwise appear to be more important for tailoring surgery than for predicting local recurrence, distant metastasis, or survival.

Discipline

Economics

Research Areas

Applied Microeconomics

Publication

Radiology

Volume

205

Issue

3

First Page

871

Last Page

875

ISSN

0033-8419

Additional URL

http://radiology.rsnajnls.org/cgi/content/abstract/205/3/871

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