Publication Type

Journal Article

Publication Date

12-2012

Abstract

Prediction of B-cell epitopes from antigens is useful to understand the immune basis of antibody-antigen recognition, and is helpful in vaccine design and drug development. Tremendous efforts have been devoted to this long-studied problem, however, existing methods have at least two common limitations. One is that they only favor prediction of those epitopes with protrusive conformations, but show poor performance in dealing with planar epitopes. The other limit is that they predict all of the antigenic residues of an antigen as belonging to one single epitope even when multiple non-overlapping epitopes of an antigen exist.

Discipline

Bioinformatics | Computer Sciences | Databases and Information Systems

Research Areas

Data Management and Analytics

Publication

BMC Bioinformatics

Volume

13

Issue

17

First Page

1

Last Page

12

ISSN

1471-2105

Identifier

10.1186/1471-2105-13-S17-S20

Publisher

BMC

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

Additional URL

http://www.biomedcentral.com/1471-2105/13/S17/S20

Comments

From Asia Pacific Bioinformatics Network (APBioNet) Eleventh International Conference on Bioinformatics (InCoB2012) Bangkok, Thailand. 3-5 October 2012

Share

COinS