Title

Neurotrophin-4/5 Treatment Reduces Infarct Size in Rats with Middle Cerebral Artery Occlusion

Publication Type

Journal Article

Publication Date

7-1996

Abstract

The aim of this study was to determine whether neurotrophin-4/5 (NT-4/5) treatment alters infarction volume following permanent focal cerebral ischemia in the rat. Permanent focal cerebral ischemia was produced in adult male rats by intraluminal occlusion of the right middle cerebral artery. NT-4/5 was administered intraventricularly one day before and immediately following occlusion. Rats were sacrificed at 1, 4 and 7 days after occlusion. NT-4/5 treatment reduced infarction volume by 34% when compared to control rats 1 day after occlusion. Infarction volume was unaltered by treatment 4 to 7 days after occlusion. Middle cerebral artery occlusion led to a significant reduction in levels of mRNAs coding for catalytic and truncated TrkB receptors. This expression was unaffected by NT-4/5 treatment.

Keywords

Neurotrophin trk receptor infarct stroke

Discipline

Medicine and Health Sciences

Research Areas

Strategy and Organisation

Publication

Neurochemical Research

Volume

21

Issue

7

First Page

763

Last Page

767

ISSN

0364-3190

Identifier

10.1007/BF02532298

Publisher

Springer Verlag (Germany)

Additional URL

http://dx.doi.org/10.1007/BF02532298

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